Note: This game is also titled Gun Survivor 4: BioHazard - Heroes Never Die.

Pause game play - To stop the game clock, enter the items screen.

Defeating Morpheus - When Morpheus is not a giant slug, use your grenade launcher or C.P. rifle. You must move constantly. Shoot him once or twice with one and move. Zigzag between the poles and avoid Morpheus' quick hand. If, however, Morpheus is able to hit you with his hand, after four or five hits, he will do a backflip away. When he does this, run immediately and heal with a Green Herb or other item.

Defeating giant Morpheus - To kill Morpheus when he becomes a giant slug-type creature, keep shooting at his eyes. Try to develop a rhythm of where his head moves. As you hit his head, he will move backwards, allowing you to defeat him.

Easy handgun kills - To kill the zombies or other creatures quicker with the hand gun, take an extra moment and aim at their head.